Publications
Lin CJ, Siddique S (2024). Parasitic nematodes: dietary habits and their implications. Trends in Parasitology 40:230-240.
, , , , , , , Root-knot nematodes produce functional mimics of tyrosine-sulfated plant peptides. PNAS, 120: e2304612120. Open Access Link.
Hasan MS, Lin Ching-Jung, Marhavy P, Kyndt T, Siddique S (2024). Redox signaling in plant-nematode interactions: insights into molecular cross talk and defense mechanisms. Plant, Cell & Environment (in press).
MR, , , , , , Phased chromosome-scale genome assembly of an asexual, allopolyploid root-knot nematode reveals complex subgenomic structure. bioRxive, doi: https://doi.org/10.1101/2023.03.20.533402. Open Access Link.
Siddique S, Radakovic Z, Hiltl C, Pellegrin C, Baum T, Beasley H, Bent A, Chitambo O, Chopra D, Danchin E, Grenier E, Habash S, Hasan M.S, Helder J, Hewezi T, Holbein J, Holterman M, Janakowski S, Koutsovoulos G, Kranse O, Lozano-Torres J, Maier T, Masonbrink R, Mendy B, Reimer E, Sobczak S, Sonawala U, Sterken M, Thorpe P, Steenbrugge JV, Zahid N, Grundler FMW, Eves-van den Akker S 2022. The genome and lifestage-specific transcriptomes of a plant-parasitic nematode and its host reveal susceptibility genes involved in trans-kingdom synthesis of vitamin B5. Nature Communications, 13: 6190. Open Access Link
Siddique S, Coomer A, Baum T, Williamson VM (2022). Recognition and Response in Plant–Nematode Interactions. Annual Review of Phytopathology, 60: 143-162. Download PDF
Hasan MS, Chopra D, Damm A, Koprivova A, Kopriva S, Meyer A, Mueller-Schuessele SJ, Grundler F, Siddique S (2022). Glutathione contributes to plant defense against parasitic cyst nematodes. Molecular Plant Pathology, 23: 1048-1059. Open Access Link
RNA isolation from nematode-induced feeding sites in Arabidopsis roots using Laser Capture Microdissection. Environmental Responses in Plants, pp 313-324.
Divykriti C, Hasan MH, Matera C, Chitambo O, Mendy B, Mahlitz D, Naz AA, Szumski S, Janakowski S, Sobczak M, Mithöfer A, Kyndt T, Grundler FMW, Siddique S (2021). Plant parasitic cyst nematodes redirect host indole metabolism via NADPH oxidase‐mediated ROS to promote infection. New Phytologist, 232: 318-331. Open Access Link
Sato K, Uehara T, Holbein J, Sasaki-Sekimoto Y, Gan P, Bino T, Yamaguchi K, Ichihashi Y, Maki N, Shigenobu S, Ohta H (2021). Transcriptomic analysis of resistant and susceptible responses in a new model root-knot nematode infection system using Solanum torvum and Meloidogyne arenaria. Frontiers in plant science. 12: 68051. Open Access Link
Marhavy P, Siddique S (2021). Histochemical Staining of Suberin in Plant Roots. Bio-protocol, doi: 10.21769/BioProtoc.3904.
Kranse O, Beasley H, Adams S, Pires-daSilva A, Bell C, Lilley CJ, Urwin PE, Bird D, Miska E, Smant G, Gheysen G, Jones J, Vineyard M, Abad P, Maier TR, Baum TJ, Siddique S, Williamson V, Akay A, Siddique S (2021). Toward genetic modification of plant-parasitic nematodes: delivery of macromolecules to adults and expression of exogenous mRNA in second stage juveniles. G3. 2021 Feb;11(2):jkaa058. Open Access Link
Shrestha A, Cudjoe DK, Kamruzzaman M, Siddique S, Fiorani F, Leon J, Naz AA (2021). Abscisic acid-responsive element binding transcription factors contribute to proline synthesis and stress adaptation in Arabidopsis. Journal of Plant Physiology, doi: 10.1016/j.jplph.2021.153414.
Hiltl C, Siddique S (2020). New Allies to Fight Worms. Nature Plants, 6:598-599. Download PDF
Hamada N, Yimer HZ, Williamson V, Siddique S (2020). Chemical hide and seek: nematode’s journey to its plant host. Molecular Plant, 13 (2):1-2 Download PDF
Singh RR, Verstraeten B, Siddique S, Tegene AM, Tenhaken R, Frei M, Haeck A, Demeestere K, Pokhare S, Gheysen G, Kyndt T (2020). Ascorbate oxidation activates systemic defence against root-knot nematode Meloidogyne graminicola in rice. Journal of Experimental Botany, 14:4271-4284. Open Access Line
Gutbrod P, Gutbrod K, Nauen R, Elashry A, Siddique S, Bentig J, Dormann P, Grundler FMW (2020). Inhibition of acetyl-CoA carboxylase by spirotetramat causes growth arrest and lipid depletion in nematodes. Sci Rep 10, 12710 . Open Access Link
Anjam MS, Shah SJ, Matera C, Rozanska E, Sobczak M, Siddique S, Grundler FMW (2020). Host factors influence the sex of nematodes parasitizing roots of Arabidopsis thaliana. Plant, Cell & Environment, 43: 1160-1174. Download PDF
Siddique S, Jones J (2020). Advances in understanding plant root response to nematode attack. “Understanding and improving crop root function”, Burleigh Dodds Science Publishing Limited.
Holbein J, Franke RB, Marhavý P, Fujita S, Górecka M, Sobcak M, Geldner N, Schreiber L, Grundler FMW, Siddique S (2019). Root endodermal barrier system contributes to defence against plant-parasitic cyst and root-knot nematodes. Plant Journal, 100:221-236. Download PDF
#This paper was selected as “Research Highlight” by the editor, Breaking or sneaking into the fortress: the root endodermis is a defence wall against nematode infection. Research Highlight
Marhavy P, Kurenda A, Siddique S, Tendon DV, Zhou F, Holbein J, Shahim HM, Grundler FMW, Farmer EE, Geldner N (2019). Single cell damage elicits regional, nematode-restricting ethylene responses in roots. EMBO J, 15: e100972. Download PDF
#This article was recommended by F1000 faculty, F1000 recommendations
Bokhari A, Essack M, Lafi FF, Andres-Barrao C, Jalal R, Alamoudi S, Razali R, Alzubaidy H, Shah KH, Siddique S, Bajic VB, Hirt H, Saad MM (2019). Bioprospecting desert plant Bacillus endophytic strains for their potential to enhance plant stress tolerance. Scientific Report, 9:18154. Open Access Link
Pogorelko GV, Juvale PS, Rutter WB, Hütten M, Maier TR, Hewezi T, Paulus J, van der Hoorn RA, Grundler FM, Siddique S, Lionetti V, Zabotina OA, Baum TJ (2019). Retargeting of a plant defense protease by a cyst nematode effector. Plant Journal, 98: 1000-1014. Download PDF
2018
Siddique S, Grundler FMW (2018). Parasitic nematodes manipulate plant development to establish feeding sites. Current Opinion in Microbiology, 46:102-108. Download PDF
Muzammil S, Shresthra A, Dadshani S, Pillen K, Siddique S, Léon J, Naz, A: An ancestral allele of Pyrroline-5-carboxylate synthase1 promotes proline accumulation and drought adaptation in cultivated barley (2018). Plant Physiology , 178:771-782. Download PDF
Pariyar SR, Nakarmi J, Anwer MA, Siddique S, Ilyas M, Elashry A, Dababat AA, Leon J, Grundler FMW (2018). Amino acid permease 6 modulates host response to cyst nematodes in wheat and Arabidopsis. Nematology, 20:737-750. Download PDF
Gutbrod P, Gutbrod K, Nauen R, Elashry A, Siddique S, Benting J, Doermann P, Grundler FMW (2018). Inhibition of acetyl-CoA carboxylase by spirotetramat causes lipid depletion and surface coat deficiency in nematodes. BioRxiv , https://doi.org/10.1101/278093. Open Access Link
Anjam MS, Shah SJ, Matera C, Rozanska E, Sobczak M, Siddique S, Grundler FMW (2018). Host factors influence the sex of nematodes parasitizing roots of Arabidopsis thaliana. BioRxiv, https://doi.org/10.1101/273391. Open Access Link
Radakovic ZR , Anjam MS , Escobar E , Chopra D , Cabrera J , Silva AC , Escobar C , Sobczak M , Grundler FMW, Siddique S (2018). Arabidopsis HIPP27 is a host susceptibility gene for the beet cyst nematode Heterodera schachtii. Molecular Plant Pathology, 19:1917-1928. Download PDF Open Access Link
Anwer MA, Anjam MS, Shah SJ, Hasan MS, Naz AA, Grundler FMW, Siddique S (2018). Genome-wide association study uncovers a novel QTL allele of AtS40-3 that affects the sex ratio of cyst nematodes in Arabidopsis. Journal of Experimental Botany, 24:1805-1814. Download PDF
2017
Shah SJ, Anjam MS, Anwer MA, Habash SS, Lozano-Torres JL, Grundler FMW, Siddique S (2017). Damage-associated responses of the host contribute to defence against cyst but not root-knot nematode infection. Journal of Experimental Botany, 16:5949–5960. Download PDF
Habash SS, Sobczak M, Siddique S, Voigt B, Elashry A, Grundler FMW (2017). Identification and characterization of a putative protein disulfide isomerase (HsPDI) as an alleged effector of Heterodera schachtii. Scientific Reports, 7:13536. Open Access Link
Dowd CC, Chronis D, Radakovic ZS, Siddique S, Schmülling T, Werner T, Kakimoto T, Grundler FMW, Mitchum MG (2017). Divergent regulation of cytokinin biosynthesis, signaling and catabolism underlying differences in feeding sites induced by cyst and root-knot nematodes. Plant Journal, 92:211-228. Download PDF
Habash SS, Radakovic ZS, Vankova R, Siddique S, Dobrev P, Gleason C, Grundler FMW, Elashry N (2017). Heterodera schachtiiTyrosinase-like protein a novel nematode effector modulating plant hormone homeostasis. Scientific Reports, 7: 6874. Open Access Link
Mendy B, Wang’ombe MW, Radakovic SZ, Holbein J, Ilyas M, Chopra D, Holton N, Zipfel C, Grundler FMW, Siddique S(2017). Arabidopsis leucine-rich repeat receptor–like kinase NILR1 is required for induction of innate immunity to parasitic nematodes. PLOS Pathogens, 13: e1006284. Open Access Link
2016
Pariyar SR, Dababat AA, Sannemann W, Erginbas-Orakci G, Elashry A, Siddique S, Morgounov A, Leon J, Grundler FMW (2016). Genome-wide association study in wheat identifies resistance to the cereal cyst nematode Heterodera filipjevi. Phytopathology, 106:1128-1138. Open Access Link
Anjam MS, Ludwig Y, Hochholdinger F, Miyaura C, Inada M, Siddique S, Grundler FMW (2016). An improved procedure for isolation of high-quality RNA from nematode-infected Arabidopsis roots through laser capture microdissection. Plant Methods, 12:25. Open Access Link
Holbein J, Grundler FMW, Siddique S (2016). Plant basal defence to nematodes: an update. Journal of Experimental Botany, 67:2049-2061. Open Access Link
Pariyar SR, Dababat AA, Siddique S, Erginbas-Orakci G, Elashry A, Morgounov A, Grundler FMW (2016). Identification and characterisation of resistance to the cereal cyst nematode Heterodera filipjevi in winter wheat. Nematology, 18:377-402. Download PDF
2015
Siddique S, Radakovic ZS, De La Torre CM, Chronis D, Novak O, Ramireddy E, Holbein J, Hütten M, Gutbrod P, Anjam MS, Rozanska E, Habash S, Elashry A, Sobczak M, Kakimoto T, Strnad M, Schmülling T, Mitchum MG, Grundler FMW (2015). A parasitic nematode releases cytokinin that controls cell division and orchestrates feeding site formation in host. PNAS, 112:12669-12674. Download PDF
Hütten M, Geukes M, Misas-Villamil JC, Van der Hoorn RAL, Grundler FMW, Siddique S.(2015) Activity profiling reveals changes in the diversity and activity of proteins in Arabidopsis roots in response to nematode infection. Plant Physiology and Biochemistry, 97:36-43. Download PDF
Ueda Y, Siddique S, Frei M (2015). A novel gene, OZONE-RESPONSIVE APOLASTIC PROTEIN 1, enhances cell death in ozone stress in rice (Oryza sativa L.). Plant Physiology, 169: 873-889. Download PDF
Kammerhofer N, Radakovic Z, Regis MAJ, Dobrev P, Vankova R, Grundler FMW, Siddique S, Hofmann J, Wieczoreck K (2015). Role of stress-related hormones in plant defence during early infection of the cyst nematode Heterodera schachtii in Arabidopsis. New Phytologist, 207: 778-789. PMC Full Text
2014 onwards
Siddique S, Matera C, Radakovic ZS, Hasan MH, Gutbrod P, Rozanska E, Sobczak M, Torres MA, Grundler FMW (2014). Parasitic worms stimulate host NADPH oxidases to produce reactive oxygen species that limit plant cell death and promote infection. Science Signaling, 7:ra33. Download PDF
Perspective: ROS open roads to roundworms infection
Worm Subverts Plant Attack
Siddique S, Endres S, Sobczak M, Radakovic ZS, Fragner L, Grundler FMW, Weckwerth W, Tenhaken, R., Bohlmann, H (2014). Myo-inositol oxygenase is important for the removal of excess myo-inositol from syncytia induced by Heterodera schachtii in Arabidopsis roots.New Phytologist, 201:476–485. PMC Full Text
Ali MA, Plattner S, Radakovic Z, Wieczorek K, Elashry A, Grundler FMW, Ammelburg M, Siddique S, Bohlmann H (2013). An Arabidopsis ATPase gene involved in nematode-induced syncytium development and abiotic stress responses. Plant Journal, 74:852-866. PMC Full Text
Elashry A, Okumoto S, Siddique S, Koch W, Kreil DP, Bohlmann H (2013). The AAP gene family for amino acid permeases contributes to development of the cyst nematode Heterodera schachtii in roots of Arabidopsis. Plant physiology and Biochemistry, 70:379-386. PMC Full Text
Siddique S, Sobczak M, Tenhaken R, Grundler FMW, Bohlmann H (2012). Cell wall ingrowths in nematode induced syncytia require UGD2 and UGD3. PLOS ONE, 7:e41515. Open Access Link
Siddique S, Wieczorek K, Szakasits D, Kreil DP, Bohlmann H (2011). The promoter of a plant defensin gene directs specific expression in nematode-induced syncytia in Arabidopsis roots. Plant Physiology and Biochemistry, 49:1100-1107. PMC Full Text
Siddique S, Endres S, Atkins JM, Szakasits D, Wieczorek K, Hofmann J, Blaukopf C, Urwin PE, Tenhaken R, Grundler FMW, Kreil DP, Bohlmann H (2009). Myo‐inositol oxygenase genes are involved in the development of syncytia induced by Heterodera schachtii in Arabidopsis roots. New Phytologist, 184:457-472. Free Access Link
Szakasits D, Siddique S, Bohlmann H (2007). An improved pPZP vector for Agrobacterium-mediated plant transformation.Plant Molecular Biology Reporter, 25: 115-120. Download PDF